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Home » Research at NEI » Neurobiology-Neurodegeneration and Repair Laboratory

Neurobiology Neurodegeneration & Repair Laboratory (N-NRL)

Anand Swaroop, Ph.D

Lab Chief: Anand Swaroop, Ph.D.

Building 10, Room 10B11/N248
Bethesda, Maryland 20892-1204
Phone: (301) 435-5754
Phone: (301) 435-6149
Fax: (301) 480-9917

Mission Statement

Neurobiology Neurodegeneration & Repair Laboratory (N-NRL) was established recently with a goal to develop novel treatment modalities for blinding retinal diseases based on fundamental understanding of genetic defects and/or biological pathways underlying differentiation, homeostasis, aging and disease pathogenesis.

Research Overview

The process of vision begins in the retina. In humans, retina supplies almost 30% of the sensory input to the brain. Any damage to retinal neurons can lead to devastating consequences, including the loss of vision. Retinal and macular diseases are a major cause of visual impairment and affect the quality of life for millions worldwide. The basic premise guiding the research of this laboratory is that clinical manifestations of disease result from perturbations in normal cellular behavior and adaptive changes to genetic variants/mutations interacting with environmental factors. With a focus on the retina, this laboratory wishes to significantly advance our understanding of several fundamentally important and interrelated biological processes and help pursue clinical interventions that utilize these advances. In particular, we seek to understand: (1) how neurons differentiate from neuroepithelial progenitors (or stem cells); (2) how these neurons form functional synaptic circuits; (3) how neuronal function is accomplished in the normal retina and how it is compromised during aging and in disease conditions; and (4) how can we repair the damage or treat the degenerative disease.

We have specifically identified the following focus areas of research:

The basic and clinical research environment at NIH provides unique opportunities to carry out innovative multi-disciplinary research that is critical for solving complex problems in biology and medicine. Our approach will be to build on strong and creative individual-specific projects yet tackle complex questions in retinal neurobiology and degeneration, which should lead to new cell, gene or small molecule based therapeutic paradigms. As retina is a relatively less complex and perhaps the most approachable part of the central nervous system, our research will complement the existing neuroscience programs at NIH.


The Chief of the Laboratory is Senior Investigator Dr. Anand Swaroop.

We expect to recruit several tenure-track investigators in the above focus areas over the next few years.

We encourage outstanding young scientists in all fields of biology (particularly computational and systems biology) to contact us for possible opportunities at NIH.

Office of the Chief

Name Title E-mail
Anand Swaroop, Ph.D.
PubMed Author Search
Lab Chief, Senior Investigator
Lucia Lawrence Administrative Lab Manager
Sharyn Ferrara Administrative Lab Manager at UM (Contractor)
Bo Chang, Ph.D. Special Guest Researcher
Jieping Wang Special Volunteer
Lori Bell Contractor
Matthew Brooks Biologist
Linn Gieser Biologist
Anastasia Krasnoperova Contractor
Jacob Nellissery, Ph.D. Biologist

Retinal Development and Genetics Section

Name Title E-mail
Anand Swaroop, Ph.D. Lab Chief, Senior Investigator
Jessica Chang HHMI Fellow
Radu Cojocaru, Ph.D. Research Fellow
James Friedman, Ph.D. Research Fellow
Dustin Hambright IRTA Fellow
Hong Hao, Ph.D. Research Fellow
Atsuhiro Kanda, Ph.D. Research Fellow
Marie-Audrey Kautzmann Graduate Student
Douglas Kim, Ph.D. Senior Research Fellow
Daniel Krauth IRTA Fellow
Chunqiao Liu, Ph.D. Senior Research Fellow
Igor Nasonkin, Ph.D. Research Fellow
Rivka Rachel, M.D., Ph.D. Staff Scientist
Jerome Roger, Ph.D. Visiting Fellow
Shobi Veleri, Ph.D. Visiting Fellow
Sharda P. Yadav, Ph.D. Visiting Fellow

2007 Publications

Journal Covers


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This page was last modified in December 2008

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